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Charles Nicole

"Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it."

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"Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it."

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Akiroq Brost

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"I had to do something for the country."

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"Born and educated in this country, I glory in the name of Briton."

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Charles Nicole
"I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced."

Man

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Charles Nicole
"Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it."

Country

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Charles Nicole
"I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals."

Success

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Charles Nicole
"The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread."

Disease

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Charles Nicole
"My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today."

Animals

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Charles Nicole
"Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread."

Nothing

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Charles Nicole
"The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal."

Discovery

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Charles Nicole
"At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used."

Time

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Charles Nicole
"It did not seem likely that I was destined to undertake research on typhus."

Research

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Charles Nicole
"Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection."

Nature

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