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"Reason can be used only when looking critically back."
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"As far as I'm concerned, the entire reason for becoming a writer is not having to get up in the morning."
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"If you follow reason far enough it always leads to conclusions that are contrary to reason."
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"He found insanity no excuse, however, for irrational behavior."
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"Behind every effect there is a cause. You can never eliminate an effect without first understanding its cause."
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"Captain Vimes believed in logic, in much the same way as a man in a desert believed in ice -- i.e., it was something he really needed, but this just wasn't the world for it."
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"It is good to be solitary, for solitude is difficult; that something is difficult must be a reason the more for us to do it."
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"Nothing guarantees that reasonable people will agree about everything, of course, but the unreasonable are certain to be divided by their dogmas. It is time we recognized that this spirit of mutual inquiry, which is the foundation of all real science, is the very antithesis of religious faith."
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"There is no society in human history that ever suffered because its people became too reasonable."
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"Religion is a distraction from true education."
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"The power of reason is thought small in these days, but I remain an unrepentant rationalist. Reason may be a small force, but it is constant, and works always in one direction, while the forces of unreason destroy one another in futile strife. Therefore every orgy of unreason in the end strengthens the friends of reason, and shows afresh that they are the only true friends of humanity."
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"The final outcome cannot be known, either to the originator of a new theory, or to his colleagues and critics, who are bent on falsifying it. Thus, the scientific innovator may feel all the more lonely and uncertain."
Loneliness


"Reason can be used only when looking critically back."
Reason


"Moreover, in the experimental sciences, the scientific fraternity must test a new theory to destruction, if possible."
Destruction


"Meanwhile, the originator of a theory may have a very lonely time, especially if his colleagues find his views of nature unfamiliar, and difficult to appreciate."
Nature
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