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Charles Nicole

"I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced."

Man,
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"I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced."

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Donna Grant

"In order that all men may be taught to speak the truth, it is necessary that all likewise should learn to hear it."

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Personal Development

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Donna Grant

"Let no such man be trusted."

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Personal Development

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Donna Grant

"Opposition may become sweet to a man when he has christened it persecution."

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Personal Development

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Donna Grant

"A little skill in antiquity inclines a man to Popery."

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Personal Development

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Donna Grant

"In the course of history, men come to see that iron necessity is neither iron nor necessary."

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Personal Development

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Donna Grant

"A man in passion rides a horse that runs away with him."

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Personal Development

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Donna Grant

"Scratch a Yale man with both hands and you'll be lucky to find a coast-guard. Usually you find nothing at all."

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Personal Development

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Donna Grant

"The man who looks for security, even in the mind, is like a man who would chop off his limbs in order to have artificial ones which will give him no pain or trouble."

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Personal Development

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Donna Grant

"The important work of moving the world forward does not wait to be done by perfect men."

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Donna Grant

"The vote is the most powerful instrument ever devised by man for breaking down injustice and destroying the terrible walls which imprison men because they are different from other men."

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Charles Nicole
"I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced."

Man

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Charles Nicole
"It did not seem likely that I was destined to undertake research on typhus."

Research

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Charles Nicole
"My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today."

Animals

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Charles Nicole
"I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals."

Success

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Charles Nicole
"Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated."

Animals

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Charles Nicole
"The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread."

Disease

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Charles Nicole
"From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus."

Today

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Charles Nicole
"Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread."

Nothing

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Charles Nicole
"Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection."

Nature

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Charles Nicole
"At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used."

Time

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