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"It is a good principle in science not to believe any 'fact'---however well attested---until it fits into some accepted frame of reference. Occasionally, of course, an observation can shatter the frame and force the construction of a new one, but that is extremely rare. Galileos and Einsteins seldom appear more than once per century, which is just as well for the equanimity of mankind."
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"There is no strife, no prejudice, no national conflict in outer space as yet. Its hazards are hostile to us all. Its conquest deserves the best of all mankind, and its opportunity for peaceful cooperation many never come again. But why, some say, the moon? Why choose this as our goal? And they may well ask why climb the highest mountain? Why, 35 years ago, fly the Atlantic? Why does Rice play Texa...s? We choose to go to the moon. We choose to go to the moon in this decade and do the other things, not because they are easy, but because they are hard, because that goal will serve to organize and measure the best of our energies and skills, because that challenge is one that we are willing to accept, one we are unwilling to postpone, and one which we intend to win, and the others, too."

"Science is simply the classification of the common knowledge of the common people. It is bringing together the things we all know and putting them together so we can use them. This is creation and finds its analogy in Nature, where the elements are combined in certain ways to give us fruits or flowers or grain."

"Man has to awaken to wonder - and so perhaps do peoples. Science is a way of sending him to sleep again."

"I hate to tell you this, but you will never actually go to a galaxy far, far away and encounter Darth Vader. That's science fiction; it isn't going to happen."

"I have been scientifically studying the traits and dispositions of the "lower animals" (so-called,) and contrasting them with the traits and dispositions of man. I find the result profoundly humiliating to me. For it obliges me to renounce my allegiance to the Darwinian theory of the Ascent of Man from the Lower Animals; since it now seems plain to me that that theory ought to be vacated in favor of a new and truer one, this new and truer one to be named the Descent of Man from the Higher Animals."

"The Cosmos is all that is or was or ever will be. Our feeblest contemplations of the Cosmos stir us -- there is a tingling in the spine, a catch in the voice, a faint sensation, as if a distant memory, of falling from a height. We know we are approaching the greatest of mysteries."

"There are no forbidden questions in science, no matters to sensitive or delicate to be probed, no sacred truths. That openness to new ideas, combined with the most rigorous, skeptical scrutiny of all ideas, sifts the wheat from the chaff. It makes no difference how smart, august, or beloved you are. You must prove your case in the face of determined, expert criticism. Diversity and debate are valued. Opinions are encouraged to contend"substantively and in depth."
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"I have a fantasy where Ted Turner is elected President but refuses because he doesn't want to give up power."

"The greatest tragedy in mankind's entire history may be the hijacking of morality by religion."

"We have to abandon the idea that schooling is something restricted to youth. How can it be, in a world where half the things a man knows at 20 are no longer true at 40 - and half the things he knows at 40 hadn't been discovered when he was 20?"

"Sometimes I think we're alone in the universe, and sometimes I think we're not. In either case the idea is quite staggering."

"Sometimes, during the lonely hours on the control deck, Bowman would listen to this radiation. He would turn up the gain until the room filled with a crackling, hissing roar; out of this background, at irregular intervals, emerged brief whistles and peeps like the cries of demented birds. It was an eerie sound, for it had nothing to do with Man; it was as lonely and meaningless as the murmur of waves on a beach, or the distant crash of thunder beyond the horizon."

"As his body became more and more defenseless, so his means of offense became steadily more frightful."
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