Francis Crick | "A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement."

"A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement."

Francis Crick, English Scientist

Agreement, Measure

7

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"A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement."

"For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few."

Class

"If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place."

Example

"The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority."

Possibility

"A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here."

Ideas

"How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons."

Nothing

"It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule."

Now

"Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap."

Now

"It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid."

May

"Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets."

Order

"We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s."

Result

"Our will makes constantly a sort of agreement with the world, whereby, if the world will continually show some respect to the will, the will shall consent to be strenuous in its industry."

Author Name

Personal Development

"That was the principle of reparations to which President Truman agreed at Potsdam. And the United States will not agree to the taking from Germany of greater reparations than was provided by the Potsdam Agreement."

Author Name

Personal Development

"We had an eyeball-to-eyeball agreement at a restaurant before I came back that, if I came back, he would never talk to me that way again or I was simply saying no."

Author Name

Personal Development

"I believe that Orthodoxy has been thinking lately, and despite other impressions, that we can't have full sacramental communion if we don't first have a fundamental agreement on the question of the primacy, that still isn't there."

Author Name

Personal Development

"The Good Friday Agreement and the basic rights and entitlements of citizens that are enshrined within it must be defended and actively promoted by London and Dublin."

Author Name

Personal Development

"Proportion is that agreeable harmony between the several parts of a building, which is the result of a just and regular agreement of them with each other; the height to the width, this to the length, and each of these to the whole."

Author Name

Personal Development

"We have to make sure the Good Friday Agreement works."

Author Name

Personal Development

"If conquest does not bind posterity, so neither can compact bind it."

Author Name

Personal Development

"It is not worth the paper it is written on unless it is backed by the kind of force that will make the other side consider the penalties too heavy to break the agreement."

Author Name

Personal Development

"The Republican movement have not behaved properly over the years. They have not themselves implemented the Agreement. If they had implemented the Agreement then they would have disarmed completely in May 2000, that is what they undertook to do, that is what they failed to do."

Author Name

Personal Development

7

Standard

Customized

More

"For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few."

Class

"If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place."

Example

"The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority."

Possibility

"A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here."

Ideas

"How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons."

Nothing

"It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule."

Now

"Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap."

Now

"It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid."

May

"Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets."

Order

"We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s."

Result

More

"Our will makes constantly a sort of agreement with the world, whereby, if the world will continually show some respect to the will, the will shall consent to be strenuous in its industry."

Author Name

Personal Development

"That was the principle of reparations to which President Truman agreed at Potsdam. And the United States will not agree to the taking from Germany of greater reparations than was provided by the Potsdam Agreement."

Author Name

Personal Development

"We had an eyeball-to-eyeball agreement at a restaurant before I came back that, if I came back, he would never talk to me that way again or I was simply saying no."

Author Name

Personal Development

"I believe that Orthodoxy has been thinking lately, and despite other impressions, that we can't have full sacramental communion if we don't first have a fundamental agreement on the question of the primacy, that still isn't there."

Author Name

Personal Development

"The Good Friday Agreement and the basic rights and entitlements of citizens that are enshrined within it must be defended and actively promoted by London and Dublin."

Author Name

Personal Development

"Proportion is that agreeable harmony between the several parts of a building, which is the result of a just and regular agreement of them with each other; the height to the width, this to the length, and each of these to the whole."

Author Name

Personal Development

"We have to make sure the Good Friday Agreement works."

Author Name

Personal Development

"If conquest does not bind posterity, so neither can compact bind it."

Author Name

Personal Development

"It is not worth the paper it is written on unless it is backed by the kind of force that will make the other side consider the penalties too heavy to break the agreement."

Author Name

Personal Development

"The Republican movement have not behaved properly over the years. They have not themselves implemented the Agreement. If they had implemented the Agreement then they would have disarmed completely in May 2000, that is what they undertook to do, that is what they failed to do."

Author Name

Personal Development