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"A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement."
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"Where force is necessary, there it must be applied boldly, decisively and completely. But one must know the limitations of force; one must know when to blend force with a maneuver, a blow with an agreement."
"Proponents of the Central America Free Trade Agreement have conveniently ignored this fundamental fact: the effect of trade on incomes in Central America and how to alleviate the adverse consequences of trade liberalization on the poor."
"The agreement to place the binational planning group at our new Northern Command was also signed in December."
"I am formally accountable to the steering board of the PIC, and I meet with nine ambassadors from the PIC every week. I have to have the capitals' broad agreement with what I do."
"There are some classified documents there that we received from the CIA. Our arrangement with the CIA was that we could by mutual agreement declassify these documents, but we had no authority to unilaterally declassify them."
"The Good Friday Agreement and the basic rights and entitlements of citizens that are enshrined within it must be defended and actively promoted by London and Dublin."
"As I learn more and more about the six-year extension of the Collective Bargaining Agreement, it's obvious to me that NFL owners understood that they were going to get a new deal done at all costs."
"There's a lot of exaggerated talk about CAFTA, but it's actually a fairly routine trade agreement. Although it involves fairly small nations, they're still more important trade partners than places like Australia or many other larger nations."
Explore more quotes by Francis Crick
"The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar."
"It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature."
"The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority."
"A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here."
"We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s."
"Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap."
"How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons."
"Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid."
"It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule."
"If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place."
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